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Motiva True Innovation:
BIA-ALCL

Believing Is Achieving

Spiran supports Innovative operative strategies to help reduce the incidence of breast implant bacterial contamination and potentially lower the risk of BIA-ALCL

Recent studies demonstrate a higher degree of biofilm formation in macro-textured implants, likely due to an increase in surface area and depth of texturing on implant surfaces. Furthermore, a chronic T-cell inflammatory infiltrate was present in studied textured implants infected with biofilm. This finding might point to chronic immune activation as a result of subclinical infection. This has potential implications for other concerns such as BIA-ALCL.

 

A number of hypotheses have been put forth to explain the genesis of BIA-ALCL.  Recent study findings have highlighted that higher surface area macro textured implant surfaces potentially carry a significantly higher risk of developing BIA-ALCL 15.

 

Biomarkers also provide evidence to show that underlying inflammation is the likely initiator of this disease 16.   The aetiology of this inflammation is yet to be determined with silicone particles17,  high friction, and biofilm12,18 all being implicated.

 

Addressing Real Concerns

Motiva Silk Surface Nano Technology has the potential to address the concerns of BIA-ALCL due to its unique biocompatibility and low frictional properties. (Motiva Biocompatibility Testing Summary).  By combining Motiva Nano-Technology, the Keller Funnel No Touch Technique and components of the 14-point plan; surgeons can have greater confidence that they are controlling as much as they can, in order to reduce the potential risks of bacterial contamination and the body’s immune response to the insertion of breast implants and associated issues.

 

For More Information

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15 Loch-Wilkinson, A.; Beath, K., William Knight Robert John, Fick Wessels William Louis, Magnusson Mark, Papadopoulos Tim, Connell Tony, Lofts Julian, Locke Michelle, Hopper Ingrid, Cooter Rodney, Vickery Karen, Joshi Preeti Avinash, Prince H. Miles and Deva Anand K.  Plastic and Reconstructive Surgery Advance Online Article May 2017. DOI: 10.1097/PRS.0000000000003654 Breast implant associated Anaplastic Large Cell Lymphoma in Australia and New Zealand – high surface area textured implants are associated with increased risk
16 Kadin ME, Deva A, Xu H, et al. Biomarkers Provide Clues to Early Events in the Pathogenesis of Breast Implant-Associated Anaplastic Large Cell Lymphoma. Aesthet Surg J. 2016;36(7):773-781.
17 Hammond D letter to editor PRS 2017
18 Hu H, Johani K, Almatroudi A, et al. Bacterial Biofilm Infection Detected in Breast Implant-Associated Anaplastic Large-Cell Lymphoma. Plast Reconstr Surg. 2016;137(6):1659-1669